Studies on the effects of media combinations on the growth and yield of Pleurotus puilmonarius an edible mushroom was carried out. The treatments compared were Grass Straw (GS), Cassava Peels (CP), Okra Chaff (OK), Maize Stover (MS), Peanut Hulls (PH), Telfaria Vine (TV), occunum Stem (OS), Wood Shaving (WS) and Maize Cob (MC). Each of these plant residues was combined with sawdust (SD) at the ratio 1:1, Sawdust (SD) only served as the control. The mixtures were treated and inoculated with actively growing mycelium of the mushroom (P. pulmnarius), incubated, cropped and harvested as the fruiting bodies appeared. The result showed that all the combinations increased both vegetative growth and fructification of the mushroom compared to the control. The biological efficiency was highest on SD+OK (56%). Total fruit weigh was highest on SD+OK (98.1g) and the least 20.5% was obtained from sawdust (control). He result obtained indicated that addition of agricultural residues of bigger particle size than sawdust boosted the performance of sawdust as the major substrate in mushroom production.